FLEXIBLE ADMINISTRATION AND ADJUSTABLE DOSING TO HELP MEET YOUR PATIENTS’ NEEDS

ACTEMRA is available in a prefilled syringe, ACTEMRA ACTPen® autoinjector, or IV administration

Dosing information for ACTEMRA IV
Use the Dosing Calculator to help determine the ACTEMRA dose for your patients.
 

ACTEMRA IV Administration

ACTEMRA is administered as a 60-minute single intravenous drip infusion. Doses exceeding 800 mg per infusion are not recommended.

Reduction of dose from 8 mg/kg to 4 mg/kg is recommended for management of certain dose-related laboratory changes including elevated liver enzymes, neutropenia, and thrombocytopenia.


Dosing information for ACTEMRA SC

ACTEMRA SC is available in a prefilled syringe or ACTPen autoinjector.

Help your patients learn how to inject their ACTEMRA SC by downloading the FDA-approved Instructions for Use.

 

ACTEMRA SC Administration

The recommended dosage for ACTEMRA SC is the same in both the prefilled syringe and the ACTPen autoinjector. Patients using ACTEMRA for subcutaneous administration should be instructed to inject the full amount in the syringe (0.9 ml) or full amount in the ACTPen autoinjector (0.9 ml), which provide 162 mg of ACTEMRA, according to the directions provided in the Instructions for Use.

Interruption of dose or reduction in frequency of administration of subcutaneous dose from every week to every other week dosing is recommended for management of certain dose-related laboratory changes including elevated liver enzymes, neutropenia, and thrombocytopenia.

It is recommended that ACTEMRA not be initiated in patients with an absolute neutrophil count (ANC) below 2000 per mm3, platelet count below 100,000 per mm3, or who have ALT or AST above 1.5 times the upper limit of normal (ULN).

ALT=alanine transaminase; AST=aspartate transaminase; SC=subcutaneous.